Todd E . Gillis , Chris D . Moyes and Glen F . Tibbits are permissive of high Ca 2 + affinity of site II Sequence mutations in teleost cardiac troponin
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چکیده
[PDF] [Full Text] [Abstract] , June 16, 2005; 22 (1): 1-7. Physiol Genomics T. E. Gillis, B. Liang, F. Chung and G. F. Tibbits troponin C Increasing mammalian cardiomyocyte contractility with residues identified in trout [PDF] [Full Text] [Abstract] , August 15, 2007; 583 (1): 337-350. J. Physiol. K. L. Kreutziger, T. E. Gillis, J. P. Davis, S. B. Tikunova and M. Regnier activation in rabbit skeletal muscle Influence of enhanced troponin C Ca2+-binding affinity on cooperative thin filament [PDF] [Full Text] [Abstract] , December 17, 2007; 32 (1): 16-27. Physiol Genomics T. E. Gillis, C. R. Marshall and G. F. Tibbits Functional and evolutionary relationships of troponin C
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Todd E . Gillis , Chris D . Moyes and Glen F . Tibbits affinity of site II 2
[PDF] [Full Text] [Abstract] , December 19, 2007; 32 (1): 16-27. Physiol. Genomics Todd E. Gillis, Christian R. Marshall and Glen F. Tibbits Functional and evolutionary relationships of troponin C [PDF] [Full Text] [Abstract] , January 1, 2007; . Cardiovasc Res Jonathan P. Davis and Svetlana B. Tikunova exchange with troponin C and cardiac muscle dynamics 2+ Ca [PDF] [Full Text] [Abstract...
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Bo Liang, Franca Chung, Yang Qu, Dmitri Pavlov, Todd E. Gillis, Svetlana B. Tikunova, Jonathan P. Davis, and Glen F. Tibbits Cardiac Membrane Research Laboratory, Kinesiology, Simon Fraser University, Burnaby; Cardiovascular Sciences, Child & Family Research Institute, Vancouver, British Columbia; Integrative Biology, University of Guelph, Guelph, Ontario, Canada; and Department of Physiology a...
متن کاملCa binding to cardiac troponin C: effects of temperature and pH on mammalian and salmonid isoforms
Gillis, Todd E., Christian R. Marshall, Xiao-Hua Xue, Thor J. Borgford, and Glen F. Tibbits. Ca binding to cardiac troponin C: effects of temperature and pH on mammalian and salmonid isoforms. Am J Physiol Regulatory Integrative Comp Physiol 279: R1707–R1715, 2000.—A reduction in temperature lowers the Ca sensitivity of skinned cardiac myofilaments but this effect is attenuated when native card...
متن کاملFunctional and evolutionary relationships of troponin C.
Striated muscle contraction is initiated when, following membrane depolarization, Ca(2+) binds to the low-affinity Ca(2+) binding sites of troponin C (TnC). The Ca(2+) activation of this protein results in a rearrangement of the components (troponin I, troponin T, and tropomyosin) of the thin filament, resulting in increased interaction between actin and myosin and the formation of cross bridge...
متن کاملBeating the cold: the functional evolution of troponin C in teleost fish.
The sensitivity of the cardiac myocyte contractile element for Ca(2+) decreases with temperature. As myocyte contractility is regulated by changes in cytosolic [Ca(2+)], this desensitizing effect represents a challenge for temperate fish such as the rainbow trout, Oncorhynchus mykiss, living in environments where temperatures are low and variable. To allow cardiac function in a temperate enviro...
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